Does thrombolytic therapy reduce infarct size?
نویسندگان
چکیده
منابع مشابه
Enzymatic infarct size and its significance for evaluation of thrombolytic therapy after acute myocardial infarction.
The February 1990 issue of Circulation contained an editorial comment by Dr. R. Roberts1 concerning our study on enzyme recovery from dog heart.2 We appreciate Roberts' interest in our study, and we agree with him that there is urgent need for methods allowing quantitative estimation of myocardial injury. We feel, however, that some of Roberts' remarks could cause confusion regarding the implic...
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Clinical assessment of patients with evolving acute myocardial infarction may suggest recanalization of the infarct coronary artery if chest pain, electrocardiographic ST-segment elevation and reperfusion arrhythmia are diminished. These 3 criteria, however, have not been correlated with immediate coronary angiography. Determination of which patients will achieve myocardial reperfusion after in...
متن کاملImproved early infarct-related vessel patency after thrombolytic therapy.
The major goal of reperfusion strategies in patients with acute myocardial infarction is to achieve patency of the infarct-related artery . Improvement in ventricular function and survival are related to initial and continued potency of this artery . The greater initial patency of the infarct-related artery after intravenous recombinant tissue-type plasminogen activator (r(-PA) compared with th...
متن کاملOxypurinol limits myocardial stunning but does not reduce infarct size after reperfusion.
To explore the role of oxygen free radicals produced by the xanthine oxidase pathway on infarct size and left ventricular function, the effect of oxypurinol, an active metabolite of allopurinol and a potent noncompetitive inhibitor of xanthine oxidase, was assessed in a 90 min, closed-chest, canine preparation of occlusion-reperfusion. Animals were randomized to receive 25 mg/kg iv oxypurinol (...
متن کاملThrombolytic therapy reduces the incidence of left ventricular thrombus after anterior myocardial infarction. Relationship to vessel patency and infarct size.
BACKGROUND Controversial evidence exists as to whether thrombolytic therapy reduces the incidence of left ventricular thrombus in acute myocardial infarction and, if so, how this relates to successful reperfusion. METHODS Four hundred and eighteen consecutive patients underwent echocardiography and coronary angiography within 3 weeks of an acute myocardial infarction. A dyssynergic score was ...
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ژورنال
عنوان ژورنال: Journal of the American College of Cardiology
سال: 1989
ISSN: 0735-1097
DOI: 10.1016/0735-1097(89)90324-0